BgI II ASS MetH 7 C 22 TCRB PATIENT 4 CONTROLS II ! ’ . IIII
نویسندگان
چکیده
Partial deletion of the long arm of chromosome 7 is a common abnormality in the bone marrow cells of patients with myelodysplastic syndrome (MDS) or acute nonlymphocytic leukemia (ANLL). This study was undertaken to characterize the chromosome breakpoints in molecular terms and to determine if hemizygosity or submicroscopic deletions occur in patients without any cytogenetically detectable abnormality of chromosome 7. We studied restriction fragment length polymorphisms with iO chromosome 7-specific DNA probes in separated WBC fractions. No molecular abnormalities occurred in lymphocytederived DNA. Several probes located in band 7q22 or distally thereof detected deletion of one allele in granulo-
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